After earning his doctorate in biochemistry in 1979, Horst Domdey worked as a scientist at various German, Swiss and US institutes such as the Max Planck Institute of Biochemistry, at ISREC, UCSD and the California Institute of Technology. From 1984 to 1994 he led an independent research group at the Gene Center of the University of Munich. In 1994 he was appointed Professor of Biochemistry at the LMU Munich. In the same year he co-founded the biotech company MediGene. In 1996 he successfully led the Munich Biotech Initiative into the German BioRegio Competition. Since 1997 he has been the Managing Director of BioM, the cluster development and management organization of the Munich Biotech Cluster. Since 2006 he also manages the Bavarian Biotechnology Network. From 2010 to 2015, he was also spokesman for the Munich m4 leading edge cluster program. Among others he is chairman of the Supervisory Board of Medigene AG, member of the Supervisory Board of the Max Delbrück Center for Molecular Medicine, and member of the boards of the Peter and Traudl Engelhorn Foundation and the Foundation for Stem Cell Research and Applied Regenerative Medicine.